Neuropeptide B-29

Where it comes from

Made in

The same neurons as NPB-23

Sent out by

With NPB-23

Acts on

• Pain and feeding circuits

What it does

• Acts like NPB-23 at both receptors, with no effect yet found that one has and the other does not ¹
• The less abundant of the two forms in the tissues examined ³
• Little studied on its own: the shorter form is what almost every experiment uses ³

In medicine

• No medicine copies it or blocks it, and it is not measured in people
• Nothing in the clinic separates it from NPB-23, and no selective ligand exists for either of the two receptors they share ³

Beyond the body’s own use

• Nothing containing it is in trials, approved or obtainable outside the laboratory
• What the receptor does is better established than what either peptide does: mice lacking NPBWR1 develop adult-onset obesity and metabolic trouble, which is the strongest evidence that this system matters at all ²
• What is unknown is whether the long form is ever released alone. It comes from the same cut of the same precursor as NPB-23, differs by six residues at one end, and no tissue or condition has been found that favours it ¹