Neuropeptide W-30

Where it comes from

Made in

The same neurons as NPW-23

Sent out by

With NPW-23

Acts on

• Hypothalamus
• Brainstem

What it does

• Acts at both receptors, a little less strongly than NPW-23 ¹
• The two forms come from one cut or two at the precursor’s end, and tissue holds both ³
• Studied in feeding and pain, almost always beside the shorter form rather than instead of it ²

In medicine

• No medicine copies it or blocks it, and it is not measured in people
• Nothing in the clinic would distinguish it from NPW-23: both act at the same two receptors, and no selective ligand for either receptor is in use ²

Beyond the body’s own use

• Nothing containing it is in trials, approved or obtainable outside the laboratory
• Its difference from NPW-23 is seven residues at one end and a modest loss of potency; no effect has been found that one has and the other does not ¹
• What is unknown is why the longer form exists. Which of the two a tissue releases depends on how far the processing enzymes go, and no condition has been found that shifts that balance, so the ratio has never been shown to mean anything ³