Phoenixin-20

Where it comes from

Made in

The same tissues as phoenixin-14

Sent out by

With phoenixin-14

Acts on

• Pituitary
• Hypothalamus
• Heart

What it does

• Acts like phoenixin-14 at the same proposed receptor, and the two are usually tested as interchangeable ¹
• Calms inflammation in cultured blood vessel lining cells, and eased pulmonary hypertension in rats ²
• Named for the phoenix, as it rose from a search of the genome rather than from tissue ¹

In medicine

• No medicine copies it or blocks it, and it is not measured in people
• Nothing in the clinic separates it from phoenixin-14: both are proposed to act at GPR173, for which no ligand is in use ³

Beyond the body’s own use

• Nothing containing it is in trials, approved or obtainable outside the laboratory
• Its own evidence is cardiopulmonary rather than reproductive: in rats given monocrotaline it lowered pulmonary artery pressure along with the inflammation and oxidative stress behind it, which is the one finding reported for the long form and not the short ²
• What is unknown is whether the two forms are ever released separately. One precursor yields both, the longer is the less studied, and no assay in use tells them apart ¹